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By William M. Lee, Roger Williams, Jean-Pierre Benhamou, Jacques Bernuau

Acute liver failure (ALF), or fulminant hepatic failure, is a unique scientific syndrome that crosses clinical disciplines. a comparatively infrequent situation, ALF is still an important concentration of scientific and learn realization. With the arrival of transplantation, the significance of realizing administration of ALF has taken on a brand new urgency. during this first quantity devoted to ALF, the editors assemble a amazing staff of members to explain the etiology, pathology and remedy of this crucial syndrome. additionally coated are consensus innovations in liver transplantation for ALF sufferers, in addition to descriptions of synthetic and bioartificial liver help units. a piece on destiny remedies contains hepatocyte transplantation, auxiliary grafts and different transitority liver help. impressive for the excessive point of the authors' services, this entire quantity may still turn out worthwhile.

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Extra resources for Acute Liver Failure

Example text

These cases, considered examples of idiosyncratic toxicity, represent only a very small proportion of patients who ingest a drug. 001 percent (NSAIDS) (Dossing and Sonne 1993). With unpredictable toxicity, there seems to be no dose relation, and usually there is no animal model. Reactions often seem to be hypersensitivity mediated, but not infrequently no evidence of hypersensitivity can be found. 1). In most cases of unpredictable hepatotoxicity, the pathogenesis is not clearly known. 1. Risk factors Genetic polymorphisms of drug metabolism acetylator and hydroxylator status Age Gender Nutrition - starvation and obesity Diseases Interactions with concomitant drugs and alcohol ally determined differences in pathways of drug metabolism, which persons are at risk for developing significant liver injury from drugs.

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Et al. 1992. Role of hepatitis C virus infection in German patients with fulminant and subacute hepatic failure. EurJClin Invest 22:569-71. F. et al. 1988. Aplastic anemia complicating orthotopic liver transplantation for non-A, non-B hepatitis. N EnglJ Med3l9: 393-6. Williams, R. and Wendon, J. 1994. Indications for orthotopic liver transplantation in fulminant liver failure. Hepatology 20: 5S-9S. , Cullens, H. et al. 1976. Enhanced HBsAb production in pathogenesis of fulminant viral hepatitis type B.

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