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By William H. Ukers

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Grach-Pogrebinsky, O. & Carmeli, S. (2008) Three novel anabaenopeptins from the cyanobacterium Anabaena sp. Tetrahedron 64, 10 233–10 238. , Kim, K. , Huber, R. & Crews, C. M. (2000) Crystal structure of epoxomicin: 20S proteasome reveals a molecular basis for selectivity of ␣,␤-epoxyketone proteasome inhibitors. Journal of the American Chemical Society 122, 1237–1238. , Shmueli, U. & Kashman, Y. (1983) Marine toxins of Latrunculia magnifica. Journal of Organic Chemistry 48, 3512–3516. Haimes, H.

2006). From the standpoint of addressing the resupply challenge of MDSMs, the total synthesis of marinomycin A has been reported (Nicolaou et al. 2006, 2007). Recently, a convergent total synthesis of 27 was disclosed, which featured the chemoselective construction of the macrodiolide dimerization (Evans et al. 2012). The differing synthetic methodologies offer entry to material 27 for future antibacterial drug development. Indoxamycin A (28) is an unusual polyketide isolated from the novel marine actinomycete strain NPS-643, from Kochi Harbor, Japan.

2011) The medicinal potential of promising marine macrolides with anticancer activity. ChemMedChem 6, 399–409. Radjasa, O. , Vaske, Y. , Vervoort, H. , Linington, R. G. & Crews, P. (2011) Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants. Bioorganic Medicinal Chemistry 19, 6658–6674. Rowley, D. , Kauffman, C. , Jensen, P. R. & Fenical, W. (2003) Halovirs A–E, new antiviral agents from a marine-derived fungus of the genus Scytalidium.

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