Download Aspects of Slow and Persistent Virus Infections: Proceedings by C. A. Mims (auth.), D. A. J. Tyrrell (eds.) PDF

By C. A. Mims (auth.), D. A. J. Tyrrell (eds.)

This e-book files the papers and discussions at a piece­ store which happened in London at the fifth and sixth of April 1979, as a part of the programme of the fee of the ecu groups on scientific and Public health and wellbeing examine. but the perspectives expressed are these of the contributors involved and never of the EEC or any of its organs. the item used to be to debate convinced organic elements of traditional and experimental sluggish virus infections. as the quantity of information and the point of interest of curiosity different in recognize of every an infection the method and emphasis various additionally. on the subject of scrapie, we mentioned the character of the agent and the mode of pathogenesis, in relation to SSPE, the hunt for strange gains of the virus, and up to date aspect­ ed paintings at the immunology of the sickness. As for Visna we reviewed the current knowing of the virus and its pathogenicity and likewise box epidemiology and strategies for its keep an eye on. there have been additionally common papers, on interferon and oncornaviruses for instance. We thank all those that made the assembly attainable and enabled us to supply this booklet speedy, in order that those that couldn't attend the assembly may possibly however manage to learn loads of what went on at it. specifically we might thank the Ciba beginning who allowed us using their premises and Mrs. Jean Ashley who handled lots of the arrangements.

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Additional info for Aspects of Slow and Persistent Virus Infections: Proceedings of the European Workshop sponsored by the Commission of the European Communities on the advice of the Committee on Medical and Public Health Research, held in London(U.K.), April 5–6, 1979

Sample text

Injection of With low levels of infection the sequence of events cannot be co mpleted within the life span . , _ injection time; - brain titre; t~JJJ - spleen - titre; survival curve. 36 The interval during which there is no detectable infectivity is provisionally designated as the "zero-phase" (6), and has also been shown in mice following transmission from another species (5,11). It is inappropriate at present to describe this as an "eclipse-phase" because of a possibility that replication may still be occurring in a different organ system has not been fully excluded.

C. or peripheral injections. c. and peripheral inoculations (46). agents which give rise to asymmetry, The in the forebrain, thalamus and cortices, produce symmetrical lesions in the brain stem and tegmentum. injection, and this suggests some localisation of the inoculum. in regions where the concentration of agent is high, early in pathogenesis, and this provides some rational basis for the finding of asymmetrical lesions in regions of the brain where 7D produces widespread lesions, namely on the mesencephalic tectum, thalamus, hippocampus, and cerebral cortex, regions in which 87A produces virtually no lesions.

However, it is now recognised that some agents give rise to a high frequency of asymmetrical lesions (Figure 8) (21, 29, 46, 48). These particular isolates are ones which induce cerebral amyloid plaques (see below) as a conspicuous feature of their pathology, although the basis of this association is unknown. An understanding of asymmetry may be crucial for elucidating some of the questions surrounding agent transport and targetting, and lesion distribution differences. g. g. c. injection of 22L matter of the cerebellum scrapie agent.

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