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By Michael Hertl

Univ. of Erlangen, Germany. Combines significant medical advances within the realizing of autoimmunity with the medical presentation and administration of problems of the outside. For clinicians and researchers. broad references, tables, figurative illustrations, and colour images are integrated.

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Absorbency of harmful immunoglobulins is a logical approach that was developed from plasmapheresis. One problem is that it acts relatively late in the immune response and B cells continue to produce pathogenic immunoglobulins. Large efforts were undertaken to develop T cell based immunotherapies. They may affect either antigen presenting cells, co-stimulation or the T cells directly. Today, strategies modulating the co-stimulation of T cells mediated through CD28/CTLA4 or LFA-2/LFA-3 seem to be one promising approach to alter autoreactive T cell responses (Abrams et al.

Epidemiology of Autoimmune Skin Disorders 27 Table 1. Interpreting Relative Risk (RR) and Odds-Ratio (OR) RR or OR <1 1 >1 Interpretation Protective factor No effect Risk factor Case-control studies are the appropriate design if a disease is rare. They are relatively easy and fast to perform, require, however, good skills in designing the study taking into account all possible sources of bias. In particular, potential risk factors associated with different surveillance, diagnosis, referral, or selection of individuals can lead to biased estimates of the relative risk and therefore to wrongful assumptions.

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