Download Bile Acids: Toxicology and Bioactivity by Gareth J Jenkins, Laura Hardie, Dennis Stamp, Peter E Ross PDF

By Gareth J Jenkins, Laura Hardie, Dennis Stamp, Peter E Ross

This publication is the 1st publication to comprehensively conceal the real homes of Bile acids and Bile acid Toxicology. Bile acids are more and more being noticeable as very important carcinogenic brokers in cancers and there's broad acceptance in their function in weight problems associated ailments. themes lined during this publication comprise synthesis and chemistry, rules and biotransformation in vivo, Bile acid precipitated mobile dying, Genotoxicity, Bile acid triggered gene expression and phone signalling abnormalities, and liver affliction, colorectal melanoma, oesophageal melanoma, and weight problems.

Show description

Read or Download Bile Acids: Toxicology and Bioactivity PDF

Similar digestive organs books

The 2002 Official Patient's Sourcebook on Diarrhea: A Revised and Updated Directory for the Internet Age

This publication has been created for sufferers who've made up our minds to make schooling and study a vital part of the therapy approach. even though it additionally provides details necessary to medical professionals, caregivers and different overall healthiness pros, it tells sufferers the place and the way to appear for info protecting almost all issues concerning diarrhea (also Bacterial diarrhea; bacterial gastroenteritis; Campylobacter enteritis; Diarrhea linked to medications; epidemic diarrhea; Factitious diarrhea), from the necessities to the main complex components of study.

The Official Patient's Sourcebook on Inguinal Hernia: A Revised and Updated Directory for the Internet Age

This e-book has been created for sufferers who've made up our minds to make schooling and study an essential component of the remedy procedure. even though it additionally offers details precious to medical professionals, caregivers and different health and wellbeing pros, it tells sufferers the place and the way to seem for info masking almost all subject matters on the topic of inguinal hernia (also Hernia - inguinal), from the necessities to the main complex parts of study.

Successful Training in Gastrointestinal Endoscopy

Endoscopy is the first diagnostic process for GI proceedings and is replete with an ever increasing array of healing services. profitable education in Gastrointestinal Endoscopy will supply all gastroenterologists with the precise set of abilities required to accomplish endoscopy on the maximum point.

Difficult Decisions in Hepatobiliary and Pancreatic Surgery: An Evidence-Based Approach

This ebook is a part of a sequence masking surgical specialties. The volumes are multi-authored, containing short chapters, each one of that are dedicated to one or particular questions or judgements inside that area of expertise which are tricky or debatable. The volumes are meant as a present and well timed reference resource for working towards surgeons, surgeons in education, and educators that describe the prompt perfect process, instead of everyday care, in chosen scientific events.

Extra resources for Bile Acids: Toxicology and Bioactivity

Sample text

J. Physiol. , 1983, 245, G681. 44. F. A. Simion, B. Fleischer and S. Fleischer, Biochemistry, 1984, 23, 6459. 45. A. Z. El-Seaidy, C. O. Mills, E. Elias and J. M. Crawford, Am. J. Physiol. , 1997, 272, G298. 46. J. M. Crawford, Y. J. Lin, B. A. Teicher, J. P. Narciso and J. L. Gollan, Biochim. Biophys. , 1991, 1085, 223. 47. A. Dietrich, W. Dieminger, K. Fuchte, G. H. Stoll, E. Schlitz, W. Gerok and G. Kurz, J. , 1995, 36, 1745. 48. A. E. Thumser and D. C. Wilton, Biochem. , 1996, 320, 729. 49.

121 The hydrophobic bile acid taurochenodeoxycholate promotes greater mucin secretion than tauroursodeoxycholate120 but similar effects on fluid secretion,122 due to activation of PKC stimulating adenylyl cyclase and leading to increased cAMP levels. Gallbladder contraction/motility has long been held to play a role in formation of gallstones in man. An investigation into 30 patients with cholesterol gallstones showed that gallbladder emptying could be used to divide the patients into strong and weak contractors, and weak contractors were associated with higher concentrations of total bile acids and phospholipids but this was unrelated to cholesterol concentration, bile-acid composition or specific 30 Chapter 2 123 species.

Keppler, J. Biol. , 2001, 276, 9626. 31. A. D. Min, K. L. Johansen, C. G. Campbell and A. W. Wolkoff, J. Clin. , 1991, 87, 1496. 32. A. W. Wolkoff, A. C. Samuelson, K. L. Johansen, R. Nakata, D. M. Withers and A. Sosiak, J. Clin. , 1987, 79, 1259. 33. W. Honscha, H. D. Platte, F. Oesch and T. Friedberg, Biochem. , 1995, 311 (Pt 3), 975. 34. M. Miyata, G. Kudo, Y. H. Lee, T. J. Yang, H. V. Gelboin, P. Fernandez-Salguero, S. Kimura and F. J. Gonzalez, J. Biol. , 1999, 274, 23963. 35. H. Zeng, G. Liu, P.

Download PDF sample

Rated 4.00 of 5 – based on 16 votes