Download Cholestasis - A Medical Dictionary, Bibliography, and by Icon Health Publications PDF

By Icon Health Publications

It is a 3-in-1 reference booklet. It provides a whole scientific dictionary masking hundreds of thousands of phrases and expressions when it comes to cholestasis. It additionally provides vast lists of bibliographic citations. eventually, it presents details to clients on find out how to replace their wisdom utilizing quite a few net assets. The ebook is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to familiarize yourself with study devoted to cholestasis. in case your time is effective, this ebook is for you. First, you won't waste time looking out the web whereas lacking loads of correct details. moment, the ebook additionally saves you time indexing and defining entries. eventually, you won't waste money and time printing hundreds and hundreds of web content.

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Extra info for Cholestasis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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The overall objective of this proposal is to test the hypothesis that oxidative stress and hepatic mitochondrial dysfunction are key elements involved in the pathogenesis of liver injury in cholestasis. In this grant renewal, we will expand our previous investigations to now examine mechanisms involved in hepatocellular apoptosis and necrosis induced by toxic bile acids that accumulate in the liver during cholestasis. We will test the following interrelated hypotheses, using freshly isolated rat and human hepatocytes, hepatic mitochondria, an intravenous bile acid toxicity model developed in our laboratory, the bile duct-ligated model of cholestasis and transgenic mice.

The current clinical management of chotestasis includes phenobarbital, which decreases hepatotoxicity as a side effect of cholestasis. I have previously demonstrated that treatment with multiple reducers of CYP2B 1/2, (transcriptionally activated by CAR) such as phenobarbital, as well as inducers of NADP(H):quinone oxidoreductase (activated through Nrf2) are also capable of inducing Mrp3, showing coordinate regulation of both the Phase I drug-metabolizing genes and Phase III xenobiotic transporters.

One of the lethal recessive mutant, fat-free, was identified at the beginning of the large-scale screen. Biochemical analysis using fluorescent lipids analogues indicate that fat-free mutation may attenuate biliary synthesis or secretion. Although three genes (FIC1, BSEP, and MDR3) responsible for infants and children with progressive familial intrahepatic cholestasis (PFIC) are identified, it remains unknown if there are undiscovered genes that are involved in bile synthesis and/or regulation may lead to PFIC.

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