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Additional resources for Clozapine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
The very distal position of the pp input, however, makes it virtually inaccessible for traditional biophysical studies. By separately studying the probability and size of individual NMDAR-mediated spine Ca2+ signals, we will be able to separately study the presynaptic and postsynaptic components of dopaminergic modulation. We can 36 Clozapine then study which dopamine receptors are responsible for each action. 3. Specific Aim 3 analyzes N-acetylaspartyl-glutamate (NAAG) modulation of the PP and the sc inputs.
Lastly, the nature of the interaction between these two schizophrenia linked signaling pathways in the modulation of Na and Ca channels will be determined. It is our thesis that these two pathways synergistically interact in ways critical to the disease process. Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ; Professor; Psychology; University of Connecticut Storrs Unit 1133 Storrs-Mansfield, Ct 06269 Timing: Fiscal Year 2002; Project Start 15-FEB-2001; Project End 31-JAN-2004 Summary: (Verbatim from the Applicant's Abstract) Clozapine is an antipsychotic drug with a unique clinical, biochemical and behavioral profile.
DA and 5HT receptors are also implicated in the neurobiology of several neuropsychiatric disorders including schizophrenia, which affects children and adolescents as well as adults. Childhood-onset schizophrenia, an uncommon form of the disease, produces severe developmental and life-long morbidity and disability. Nevertheless, the neuropathology and pathophysiology of juvenile schizophrenia are far less well studied than in the adult disorder largely owing to the lack of access to postmortem brain tissue from young patients.