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By Fahad Al-Obeidi, John F. Okonya, Richard E. Austin, Dan R. S. Bond (auth.), Lisa Bellavance English (eds.)

By considerably expanding the variety of pursuits on hand for drug discovery, the Human Genome and Proteome tasks have made using combinatorial libraries necessary to constructing and optimizing drug candidate molecules extra speedily. Lisa English and a panel of specialist researchers have gathered in Combinatorial Library tools and Protocols a singular sequence of computational and laboratory equipment for the layout, synthesis, quality controls, screening, and purification of combinatorial libraries. the following the reader will locate state of the art recommendations for the instruction of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There also are cutting-edge tools for computational library layout, quality controls via mass spectrometry, and constitution verification utilizing 1D and 2nd NMR. various recognized computational ways are supplied to satisfy the knowledge administration problem of a number of organic assays. every one effectively reproducible procedure contains exact step by step directions and worthy notes on troubleshooting and warding off pitfalls.
well timed and hugely functional, Combinatorial Library tools and Protocols makes on hand for all drug discovery researchers all of the strong combinatorial chemistry instruments which are expanding the variety of candidate compounds and dashing the method of drug discovery and improvement today.

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Lipinski, C. , Dominy, B. , and Feeney, P. J. (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Delivery Rev. 23, 3–25. 39. Egan, W. , Merz, K. , and Baldwin, J. J. (2000) Prediction of drug absorption using multivariate statistics. J. Med. Chem. 43, 3867–3877. 40. Dolle, R. , Bowman, K. , Egan, W. , Cavallaro, C. , Roughton, A. , Reader, J. , and Carroll C. D. (2000) A statistical-based approach to assessing the fidelity of combinatorial libraries encoded with electrophoric molecular tags.

J. (1999) Comprehensive survey of combinatorial library synthesis: 1998. J. Comb. Chem. 1, 235–282. 7. Dolle, R. E. (1999) Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997. Annu. Rep. Comb. Chem. Mol. Diversity 2, 93–127. 8. Fecik, R. , Frank, K. , Gentry, E. , Menon, S. , Mitscher, L. , and Telikepalli, H. (1998) The search for orally active medications through combinatorial chemistry.

Jan/Feb, 55–60. 4. Floyd, C. , and Whittaker, M. (1999) Combinatorial chemistry as a tool for drug discovery, in Progress in Medicinal Chemistry (King, F. D. and Oxford, A. ), Elsevier Science, Amsterdam, Vol. 36, pp. 91–168. 5. Dolle, R. E. (2000) Comprehensive survey of combinatorial library synthesis: 1999. J. Comb. Chem. 2, 383–433. 6. Dolle, R. E. and Nelson, K. H. J. (1999) Comprehensive survey of combinatorial library synthesis: 1998. J. Comb. Chem. 1, 235–282. 7. Dolle, R. E. (1999) Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997.

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